Electronic ISSN 2287-0237

VOLUME

THERAPEUTIC APPLICATIONS OF DENTAL PULP STEM CELLS IN VETERINARY MEDICINE: A CASE REPORT

FEBRUARY 2015 - VOL.9 | REVIEWS ARTICLE

The application of stem cells treatment has been a considerable research focus over the last decade. Several stem cell types have been studied as the potential candidates to restore the structure and function of damaged tissues and organs. The dental pulp stem cells (DPSCs) have shown potential for their use as a novel alternative resource in dentistry and regenerative medicine. DPSCs have mesenchymal stem cell-like (MSC) qualities, including the capacity for self-renewal and multilineage differentiation potential. In this study,  we  demonstrate the potential applications of DPSCs as a   tool to repair damaged tissues and organs. Diseases related to chronic inflammation such as ischemic heart diseases, osteoarthritis, tendonitis, ocular injury and chronic wounds have been investigated through experimental and clinical trial design to clarify the use of DPSCs therapies. Transplantation of DPSCs provided a good choice in terms of tissue regeneration and healing. Our findings suggested that DPSCs might provide a new  perspective  for  translational  medicine.  However,  important  points in DPSCs biology, such as homing and immune-regulation require further study of underlying mechanisms to support the application of DPSCs in the future.

Keywords:

dental pulp, stem cells, cell therapies

MEDIA
Figure 1:
Photomicrograph of dental pulp stem cells (DPSCs) isolated from pulps tissue of the dog teeth. Cells aligned close to the pulp tissue showed in primary culture (A) and become semi-confluent in 25 cm2 flasks in 4-6 days (B).17
Figure 2:
Effect of SHEDs intravenous injection on scar tissue (A); represented heart section from untreated group (Control) compared to single SHEDs-treated (SHED-s) and multiple-treated (SHED-m), Values are mean ± SEM, *p < 0.05 and **p < 0.01. Correlation among Fraction Shortening (FS) in (B) and Heart Rate Variability in (C).
Figure 3:
Radiographic findings before pDSCs injection in (A) and after pDSCs injection in (B) present subchondral sclerosis (black arrow), osteophyte formation on distal femur (white arrow).17
Figure 4:
Corncal Ulcer post injection of DPSCs via sub-conjunctiva route resulted in healing within 7 days
Figure 5:
Chronic wound injections of DPSCs promoted wound healing after day 28 and the healing capacity was improved throughout the follow-up
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