Electronic ISSN 2287-0237

VOLUME

INTRA-LESIONAL NSAIDS INJECTION: UNREPORTED TREATMENT IN (EXTRA-ABDOMINAL) DESMOID TUMORS.

SEPTEMBER 2016 - VOL.12 | CASE REPORT

Desmoid tumors are a rare benign tumor that can be locally aggressive and cause morbidity to a patient. The best way of treatment, whether surgical or non-surgical, has yet to be found. We report an unreported method of treatment in (extra-abdominal) desmoid tumor which showed a positive result. Our patient presented with (extra- abdominal) desmoid tumor on her left forearm that caused her pain and paresthesia in the left forearm. The mass was located near an important neurovascular structure making the authors opt for conservative management. Desmoid tumor cells show expression of COX-2 and beta-catenin. NSAIDs the COX enzyme inhibitors are used orally to conservatively treat (extra-abdominal) desmoid tumor. To our knowledge, NSAIDs have never been used locally. Here we report our treatment of (extra-abdominal) desmoid tumor by injecting NSAIDs directly into the tumor and follow up on the clinical and radiographic study of the patient. This diversion of treatment, which had never been done before, showed a positive outcome in decreasing symptoms and size of the tumor in our patient. In this reported case, local NSAIDs injection into (extra- abdominal) desmoid tumor showed a positive result. We hope this case report can lead to a further study of this way of treatment and we hope that this report could be a path to a further study for the cure of desmoid tumors.

 

Keywords:

extra-abdominal, desmoid, fibromatosis, NSAIDs, soft tissue tumor.

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Figure 1:
High magnification of the tumor specimen reveals a spindle cell lesion with pale nuclei which have low cellularity and abundant collagen. There was no definite malignancy seen in the specimen which suggested a desmoid tumor.
Figure 2:
Axial view of the tumor in T1 and T2 (pulse sequences) from MRI study prior to and after 6 doses of treatment showing a decrease of tumor dimensions. A and C are images prior to the treatment. B and D are images after 6 doses of treatment.
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