Electronic ISSN 2287-0237




To study the preliminary results of 20 patients who underwent Anterior Lumbar Interbody Fusion (ALIF) and were followed up for more than 6 months at the Bangkok Spine Academy.


Study of the preliminary results and retrospective chart review of collected clinical and radiographic outcomes in 20 patients who underwent ALIF L1-L5 at Bangkok Hospital from April 2011 to April 2013 as a treatment for degenerative disc disease, spondylolisthesis, recurrent disc herniation and failed back surgery syndrome. Treatment involved using a stand-alone polyetheretherketone (PEEK) cage and an anterior plate construct (Synfix®, Synthes spine, PA, USA).


Of 22 patients who underwent ALIF surgery between April 2011 and April 2013 two were excluded from this series. The remaining 20 cases were followed up regularly until the fusion was complete.

   Indications for surgery were degenerative disc disease, spondylolisthesis, pseudarthrosis from previous surgery, and recurrent disc herniation. Most cases experienced both back pain and leg pain from spinal instability and nerve root compression. Five cases underwent surgery because of back pain without any leg pain. The majority of patients (nine cases, 45% of total) were spondylolisthesis, including both degenerative and lytic types. Seven cases (35%) were diagnosed as degenerative disc disease. One case (5%) was treated because of the recurrence of disc herniation. One case (5%) was treated for pseudarthrosis and an implant breakage from previous fusion surgery.

   In a total of 20 cases we operated on 23 levels of problematic discs. The mean operative time for each level was 156 (±35.5) minutes (mean ± standard deviation (SD)). The shortest operative time was 115 minutes for each level and the longest was 240 minutes. The intraoperative blood loss averaged at 315.2 (±225) ml.

   The initial pain score in self-reported questionnaires (visual analog scale (VAS) back, VAS legs) showed fast and lasting pain relief. The mean VAS preoperative back score was 5.7 (±2.0), which at the two-week visit reduced to 0.6 (±1.1). The mean VAS leg score was 3.55 (±2.8), which reduced to 0.1 (±0.2).

   The Oswestry Disability Index (ODI) questionnaire was used to evaluate the improvement of the overall disability status and was found to decrease from 42.0 (±28.2) to 13.9 (±14.3) at the six-week follow up visit. It continued to decrease to 4.3 (±6.4) at the threemonth visit and 0.4 (±1.0) at the six-month visit. There was a mean correction of segmental lordosis at an instrumented level from an initial 18.6 (± 8.8) to 21.2 (±8.7) after surgery. There was a significant improvement in the mean coronal angle from 4.1 (±4.5) to 1.6 (±2.0) postoperatively. The increase in mean disc height at the middle column was from 8.8 (±3.2)mm to 14.4 (±2.1)mm after surgery. The degree of slip changed from a mean of 16.7 (±5.6)% to 8.4 (±5.9)%, and the average slip improvement was 49.7 (±27.9)% using the standalone ALIF technique.

   One of the most challenging aspects of this surgery is the difficulty of an anterior retroperitoneal approach. The large venous and arterial channels obstruct exposure of the lumbar intervertebral disc. Of the 22 cases, one had inadvertent intraoperative venous bleeding from an old adhesion from a previous surgery but this was controlled by a vascular surgeon. There were no cases with an abdominal ileus after surgery. One case had retrograde ejaculation that was resolved during the second year follow up visit. There were no cases of neurological problems as this surgery went in from the front of the spine. Because the ALIF implant is large it carries the human body very well, so there were no cases of subsidence, implant breakage or loosening. The fusion was well established because of a big area of fusion on the vertebral end plate. The nature of this surgical technique ensures the patient experiences less back pain after surgery which in turn improves their ability to recover faster and to return to their full activity.


This preliminary mid-term report of the stand-alone ALIF procedure at the Bangkok Spine Academy shows satisfactory and consistent results. The benefits of this procedure include: reduction in back and leg pain, minimization of soft tissue injuries especially of uninjured back muscle, and lower likelihood of nerve root injuries. The only disadvantage of this procedure is that the technically demanding anterior approach needs prompt management for any vascular issues. These surgical techniques show fast and long-lasting, satisfactory results with less likelihood of long-term complications. 


anterior lumbar interbody fusion, ALIF



Figure 1: Stand alone ALIF PEEK cage with anterior plate construct (Synfix®) available in Thailand.
Figure 2: Synfix®, stand alone PEEK cage with anterior plate construct was filled with bone graft substitute, Bone Morphogenetic Protein (white).
Figure 3: Mini-opened surgery on the front by retroperitoneal approach can expose the entire anterior surface of the pathological disc.
Figure 4: In a case of suspected variation of the great vessel on the front of the spine, the magnetic resonance angiography is considered.
Figure 5: One of the good case for ALIF is lumbar spondylolisthesis grade 1 - 2 with or without radiculopathy. This surgery is able to reduce the slip level to normal alignment and also decompression the neural foramen.
Figure 6: For the mini-opened anterior approach to the lumbar spine, the Synframe retractor is one of the instruments needed for good exposure.
Figure 7: The proper size of PEEK age with anterior plate construct (Synfix®) was inserted into the affected disc and fixed with screws.
Table 1: Demographic and Clinical data.
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Figure 11: ALIF has advantages in term of solid fusion. This picture shows solid interbody fusion after 6 month stand alone ALIF with rh-BMP2.
Figure 12: Stand alone ALIF is also suitable for lytic spondylolisthesis. The pictures show acceptable reduction of slip and solid fusion 6 months later.