Electronic ISSN 2287-0237

VOLUME

EFFICIENCY OF COMBINING TRASTUZUMAB WITH CHEMOTHERAPY IN CASE OF ADVANCED GASTRIC CARCINOMA WITH LOW LEVEL AMPLIFICATION HER2 (C-ERB-B2 PROTEIN)

FEBRUARY 2012 - VOL.3 | CASE REPORT
  1. Cabebe E.C. Gastric cancer at http://emedicinemed scape.com/Article/278744-overview.
  2. Slamon DJ, Godolphin W, Jones LA, et al. Studies of the HER-2/neu proto-oncogene in human breast and ovarian cancer. Science 1989;244:707-12.
  3. Nelson NJ. Can HER2 Status Predict Response to Cancer Therapy?. J Natl Cancer Inst 2000;92:366-7.
  4. Menard S, Casalini P, Campiglio M, et al. HER2 overexpression in various tumor types, focussing on its relationship to the development of invasive breast cancer. Ann Oncol 2001;12 (Suppl 1):15-9.
  5. Scholl S, Beuzeboc P, Pouillart P. Targeting HER2 in other tumor types. Annals of oncology 2001;12:81-7.
  6. Tanner M, Hollmen M, Junttila TT, et al. Amplification of HER-2 in gastric carcinoma: association with Topoisomerase IIalpha gene amplification, intestinal type, poor prognosis and sensitivity to trastuzumab. Ann Oncol 2005;16:273-8.
  7. Menendez JA, Mehmi I, Lupu R. Trastuzumab in combination with heregulin-activated Her-2 (c-erbB-2) triggers a receptor-enhanced chemosensitivity effect in the absence of Her-2 overexpression. J Clin Oncol 2006;24:3735-46.
  8. Bang YJ, Cutsem EV, Feyereislova A, et al. Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): a phase 3, open-label, randomised controlled trial. The Lancet 2010;376:687-97.
  9. Negri FV, Bozzetti C, Ardizzoni A, et al. HER-2 discordance between primary gastric carcinoma and paired lymph node metastasis. Hum Pathol 2009; 40:769-77.
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