Electronic ISSN 2287-0237

VOLUME

A PROSPECTIVE RANDOMIZED TRIAL FOR REDUCTION OF SERUM LOW DENSITY LIPOPROTEIN (LDL) WITH PLANT STANOL ESTER MIXED IN COFFEE IN A HYPERCHOLESTEROLEMIC THAI POPULATION.

FEBRUARY 2013 - VOL.5 | ORIGINAL ARTICLE
OBJECTIVE:

To determine whether replacing ordinary coffee with coffee mixed with the plant stanol ester decreases the serum low density lipoprotein (LDL) level in moderately hypercholesterolemic Thais.

MATERIALS AND METHODS

A randomized, double-blind, placebo-controlled trial of a common daily coffee was conducted on May 1, 2012 with continued treatment and follow-up through June 1, 2012. A total of 54  Thais  whose serum  LDL levels ranged from 130 to 239 mg/dL at randomization, were enrolled and randomized into two groups. The participants consumed a cup of plant stanol mixed coffee or a cup of placebo coffee once a day. The percentage of serum LDL reduction was measured at the end of the study.

RESULTS:

Thirty-three subjects were randomized into each group. Forty-seven subjects completed the study, 30 in the group receiving coffee with added plant stanols as ester and 17 in the placebo coffee group. Statistical analysis was done by unpaired t-test using PASW (Predictive Analytics SoftWare) Statistics 18 (SPSS Inc., IL, USA). The results showed a significant difference in mean reduction of LDL levels (p < 0.001, 95% CI = 6.92 – 18.57). The means were 12.77% in the first group and 0.03% in the second group (SD = 9.33 and 9.88, respectively).

CONCLUSION:

Among this population of hypercholesterolemic Thais, the daily replacement of an ordinary cup of coffee with a plant stanol mixed coffee reduced serum LDL levels by 12.77% demonstrating the efficacy of the cholesterol-lowering ingredient in the new food matrix.

Keywords:

plant stanol ester, coffee, LDL, hypercholesterolemia, Thai

MEDIA
Figure 1:
Subject eligibility and adherence
Table 1:
Basic characteristics and initial measurements of analyzed subjects
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