Electronic ISSN 2287-0237

VOLUME

TREATMENT OUTCOMES AND RISK FACTORS RELATED TO MORTALITY AND TREATMENT FAILURE OF PATIENTS INFECTED WITH ACINETOBACTER BAUMANNII AT A GENERAL HOSPITAL

SEPTEMBER 2019 - VOL.15 | ORIGINAL ARTICLE
OBJECTIVES

This retrospective study aimed to explore clinical outcomes and risk factors associated with mortality and treatment failure among A. baumannii infected patients.

MATERIAL AND METHODS

This retrospective study gathered the data of patients infected with A. baumannii, during the period from January 2014 to December 2015, admitted at Hua Hin hospital. Patient data reviewed included demographic data, antimicrobial regimens, antimicrobial susceptibility, length of hospitalization, source of infections, and clinical outcomes. The primary outcome measurements were in-hospital mortality and risk factors related to failure and mortality.

RESULT

One hundred and forty-five patients were included in the study. Of our results, pneumonia was the most common site of infection (80.7%). The in-hospital mortality and treatment failure rates were 43.4% and 52.4%, respectively. For logistic regression analysis, shock was a statistically significant risk factor associated with treatment failure (adjusted odd ratios 3.10, 95%CI 1.21-7.97) and in-hospital mortality (aOR 4.96; 95%CI 1.74-14.14). Whereas age ≥ 65 years (aOR 2.21; 95% 1.06-4.64) was only associated with in-hospital mortality.

CONCLUSION

Septic shock and patients aged ≥ 65 years old were associated with unfavourable treatment outcomes in patients with A. baumannii infections. Thus, this critical condition needs to be addressed and measures taken to improve outcomes of A. baumannii treatment.

Keywords

A. baumannii, mortality, treatment failure, combination therapy

Received: March 1, 2019

Revision received: March 18, 2019

Accepted after revision: May 27, 2019

BKK Med J 2019;15(2): 154-157.

DOI: 10.31524/bkkmedj.2019.09.005

SEARCH VOLUME & NUMBER
GO
RECENT VOLUME & NUMBER