Received: Janaury 4, 2018 Revision received: Janaury 8, 2018 Accepted after revision: Janaury 11, 2018
BKK Med J 2018;14(1):1-4.
The aim of this study was to evaluate potential skin sensitization and collagen synthesis of rats receiving proteoglycan (PG) serum.
Eighteen rats were randomly divided into 3 groups equally and assigned to receive 1 ml of serum base (control), 1% PG and 2% PG applied to skin. Histological analysis was evaluated for potential skin sensitization and collagen synthesis on days 7, 14, 21 and 28.
Histological analysis showed that 1% PG and 2% PG accelerated collagen synthesis. The evaluation of potential skin sensitization, on day 7, 14, 21 and 28 of rat applied with 1% PG and 2% PG were not significantly different when compared to the control group.
This study demonstrated that PG serum accelerated collagen synthesis and low potential skin sensitization.
proteoglycans, collagen synthesis, potential skin sensitization, Trichopoduspectoralis
Faculty of Science and Technology, Bansomdejchaopraya Rajabhat University,
1061 Isaraphab 15 Rd. Dhonburi, Bangkok 10600, Thailand.