Electronic ISSN 2287-0237

VOLUME

MRI FINDINGS IN TRANSIENT GLOBAL AMNESIA

FEBRUARY 2016 - VOL.11 | CASE REPORT

Transient global amnesia (TGA) is characterized by an attack of temporary antero- grade amnesia without other focal neurological deficits. Characteristic magnetic resonance imaging (MRI) findings include small, punctate, unilateral or bilateral diffusion restriction in the lateral aspect of the hippocampus, which mostly occurs within 48 hours after symptoms onset. The outcome of TGA is usually excellent. The pathophysiology of TGA remains uncertain, but recent evidence suggests that this disorder may result from the inability to generate new memory in the hippocampus due to vulnerability of CA-1 neurons to metabolic stress.

Keywords:

transient global amnesia; MRI, hippocampus

MEDIA
Figure 1:
The MRI diffusion weighted imaging (DWI) showed small punctuate hyper-intense lesions in the CA1 area of the bilateral hippocampi. (b value = 1000 s/mm2, 2-mm slice through the hippocampus, performed at approximately 12 hours after symptom onset).
Figure 2:
The MRA of the brain was unremarkable.
Figure 3:
The MRV of the brain revealed hypoplasia of the left transverse and sigmoid sinuses, which could be a normal variation.
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