Electronic ISSN 2287-0237

VOLUME

AA AMYLOIDOSIS IN SYSTEMIC LUPUS ERYTHEMATOSUS CASE PRESENTATION INTERHOSPITAL RENAL CLINICOPATHOLOGICAL CONFERENCE (1/2016)

FEBRUARY 2016 - VOL.11 | SPECIAL FEATURE7

We report on a 62-year-old female with a 10-year history of hypertension and of systemic lupus erythematosus with Sjogren’s syndrome for 5 years. Her current visit showed worsening anemia with severe proteinuria and deterioration of renal function. Renal biopsy showed deposition of amyloid A as demonstrated by immunohistochemical staining with amyloid A specific antibody and electron microscopy. Immunofluorescence microscopy revealed deposition of C3, leading to the diagnosis of AA amyloidosis secondary to SLE. The patient received colchicine for one month and she did not follow-up.

Keywords:

AA Amyloidosis in systemic lupus erythematosus

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Figure 1:
Glomerular deposition of eosinophilic fibrillar material (H&Ex200).
Figure 2:
Glomerular deposition of eosinophilic fibrillar material in glomerular structure and periglomerular fibrotic tissue (H&Ex200).
Figure 3:
Deposition of C3 in glomerulus (IFx200).
Figure 4:
Deposition of amyloid A in glomerulus (IHCx200).
Figure 5:
Deposition of amyloid A in peritubular and inter- stitium (IHCx200).
Figure 6:
Electron microcopy demonstrating deposition of non-branching 8-12 nm typical of amyloid fibrils in arterio- lar wall (TEMx40,000).
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